|Sepedonium species are common but comprise a small proportion of the fungal biota. This genus is somewhat related to Chrysosporium and Staphylotrichum. It also bears a superficial resemblance to Histoplasma capsulatum, an important pathogen found primarily in the midwestern United States. May be identified on surfaces by tape lifts, tease mounts from bulk samples, and in air by culturable (Andersen) and spore trap samples. (Spores have distinctive morphology.) Natural habitat is soil, coniferous wood, and mushroom compost. Commonly parasitic on mushrooms in the Agaricaceae and Boletaceae as well.